State Street SPDR S&P Biotech ETF (XBI)

XBI Holdings List

As of Dec 4, 2025

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No.	Symbol	Name	% Weight	Shares
1	EXAS	Exact Sciences Corporation	2.78%	2,160,897
2	RVMD	Revolution Medicines, Inc.	2.64%	2,644,072
3	RNA	Avidity Biosciences, Inc.	2.33%	2,550,676
4	NTRA	Natera, Inc.	2.15%	697,090
5	BBIO	BridgeBio Pharma, Inc.	2.13%	2,234,767
6	INSM	Insmed Incorporated	2.12%	811,045
7	MDGL	Madrigal Pharmaceuticals, Inc.	2.06%	275,161
8	REGN	Regeneron Pharmaceuticals, Inc.	1.96%	212,929
9	IONS	Ionis Pharmaceuticals, Inc.	1.93%	1,849,325
10	BIIB	Biogen Inc.	1.92%	829,917
11	ROIV	Roivant Sciences Ltd.	1.86%	6,887,759
12	AMGN	Amgen Inc.	1.84%	424,974
13	UTHR	United Therapeutics Corporation	1.84%	298,522
14	VRTX	Vertex Pharmaceuticals Incorporated	1.78%	304,611
15	EXEL	Exelixis, Inc.	1.78%	3,139,504
16	INCY	Incyte Corporation	1.76%	1,372,152
17	CRSP	CRISPR Therapeutics AG	1.68%	2,268,669
18	NBIX	Neurocrine Biosciences, Inc.	1.65%	838,051
19	ABBV	AbbVie Inc.	1.63%	559,229
20	GILD	Gilead Sciences, Inc.	1.60%	1,026,931
21	MRNA	Moderna, Inc.	1.58%	4,868,654
22	ALNY	Alnylam Pharmaceuticals, Inc.	1.50%	252,196
23	BMRN	BioMarin Pharmaceutical Inc.	1.49%	2,171,626
24	PTCT	PTC Therapeutics, Inc.	1.47%	1,485,000
25	VKTX	Viking Therapeutics, Inc.	1.44%	2,931,634

As of Dec 4, 2025

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