SPDR S&P BIOTECH ETF (XBI)

XBI Holdings List

As of May 9, 2025

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No.	Symbol	Name	% Weight	Shares
1	EXAS	Exact Sciences Corporation	3.06%	2,853,444
2	NBIX	Neurocrine Biosciences, Inc.	2.92%	1,212,608
3	NTRA	Natera, Inc.	2.89%	915,267
4	ALNY	Alnylam Pharmaceuticals, Inc.	2.85%	545,570
5	UTHR	United Therapeutics Corporation	2.70%	430,708
6	BPMC	Blueprint Medicines Corporation	2.46%	1,215,310
7	INSM	Insmed Incorporated	2.42%	1,786,280
8	INCY	Incyte Corporation	2.39%	1,952,646
9	ABBV	AbbVie Inc.	2.39%	623,633
10	VRTX	Vertex Pharmaceuticals Incorporated	2.36%	266,938
11	AMGN	Amgen Inc.	2.34%	423,235
12	GILD	Gilead Sciences, Inc.	2.34%	1,160,207
13	BIIB	Biogen Inc.	2.32%	943,439
14	MDGL	Madrigal Pharmaceuticals, Inc.	2.24%	365,911
15	EXEL	Exelixis, Inc.	2.12%	2,816,497
16	REGN	Regeneron Pharmaceuticals, Inc.	2.10%	191,804
17	BMRN	BioMarin Pharmaceutical Inc.	1.96%	1,602,299
18	MRNA	Moderna, Inc.	1.90%	3,777,656
19	HALO	Halozyme Therapeutics, Inc.	1.86%	1,359,552
20	BBIO	BridgeBio Pharma, Inc.	1.76%	2,473,249
21	RVMD	Revolution Medicines, Inc.	1.68%	1,999,586
22	TGTX	TG Therapeutics, Inc.	1.56%	2,225,286
23	IONS	Ionis Pharmaceuticals, Inc.	1.45%	2,156,569
24	SMMT	Summit Therapeutics Inc.	1.40%	2,811,110
25	ROIV	Roivant Sciences Ltd.	1.34%	6,065,955
26	CRSP	CRISPR Therapeutics AG	1.32%	1,786,832
27	SWTX	SpringWorks Therapeutics, Inc.	1.31%	1,357,297
28	VKTX	Viking Therapeutics, Inc.	1.29%	2,248,751
29	CYTK	Cytokinetics, Incorporated	1.19%	1,804,670
30	ALKS	Alkermes plc	1.15%	1,840,940
31	ADMA	ADMA Biologics, Inc.	1.14%	2,732,785
32	PCVX	Vaxcyte, Inc.	1.04%	1,612,870
33	RNA	Avidity Biosciences, Inc.	1.03%	1,772,047
34	NUVL	Nuvalent, Inc.	0.91%	626,411
35	SLNO	Soleno Therapeutics, Inc.	0.91%	567,211
36	SRPT	Sarepta Therapeutics, Inc.	0.90%	1,192,599
37	ACAD	ACADIA Pharmaceuticals Inc.	0.89%	2,450,823
38	SRRK	Scholar Rock Holding Corporation	0.87%	1,366,397
39	ACLX	Arcellx, Inc.	0.86%	715,874
40	RYTM	Rhythm Pharmaceuticals, Inc.	0.84%	706,434
41	VCYT	Veracyte, Inc.	0.84%	1,357,866
42	KRYS	Krystal Biotech, Inc.	0.81%	295,699
43	CRNX	Crinetics Pharmaceuticals, Inc.	0.80%	1,249,683
44	RARE	Ultragenyx Pharmaceutical Inc.	0.79%	1,086,683
45	APLS	Apellis Pharmaceuticals, Inc.	0.79%	2,204,171
46	TWST	Twist Bioscience Corporation	0.78%	1,214,809
47	AKRO	Akero Therapeutics, Inc.	0.75%	906,430
48	TVTX	Travere Therapeutics, Inc.	0.74%	1,774,490
49	RXRX	Recursion Pharmaceuticals, Inc.	0.66%	7,322,380
50	AGIO	Agios Pharmaceuticals, Inc.	0.65%	1,145,654

As of May 9, 2025

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