Ionis Pharmaceuticals, Inc. (FRA:ISI)

Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions EUR. Fiscal year is January - December.

Fiscal Year	Current	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Period Ending	Dec 3, 2025	Dec 31, 2024	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021	Dec 31, 2020
Market Capitalization	11,373	5,332	6,567	5,020	3,778	6,463
Market Cap Growth	125.70%	-18.80%	30.80%	32.87%	-41.54%	-14.65%
Enterprise Value	11,214	4,853	6,325	4,333	3,171	5,408
Last Close Price	70.80	34.12	45.57	34.90	26.95	46.40
PS Ratio	13.80	7.83	9.22	9.13	5.30	10.84
PB Ratio	21.59	9.38	18.77	9.37	5.57	10.64
P/TBV Ratio	21.59	9.38	18.77	9.37	5.57	11.05
P/FCF Ratio	-	-	-	-	228.03	10240.42
P/OCF Ratio	-	-	-	-	139.52	220.26
EV/Sales Ratio	13.49	7.13	8.88	7.88	4.45	9.07
EV/FCF Ratio	-43.47	-	-	-	191.38	8569.00
Debt / Equity Ratio	3.33	3.33	5.09	2.39	1.62	1.26
Debt / FCF Ratio	-	-	-	-	66.39	1217.15
Asset Turnover	0.32	0.24	0.28	0.23	0.32	0.26
Inventory Turnover	45.90	91.49	61.67	36.18	27.98	0.60
Quick Ratio	2.51	7.74	5.44	6.49	9.13	3.30
Current Ratio	2.79	8.47	5.90	7.07	9.75	3.56
Return on Equity (ROE)	-40.04%	-93.10%	-76.34%	-40.12%	-3.77%	-39.52%
Return on Assets (ROA)	-5.68%	-9.91%	-7.55%	-9.96%	-0.75%	-3.82%
Return on Capital (ROIC)	-6.51%	-12.12%	-9.71%	-12.93%	-1.02%	-5.18%
Return on Capital Employed (ROCE)	-13.10%	-17.60%	-13.10%	-18.50%	-1.30%	-9.60%
Earnings Yield	-1.92%	-8.22%	-5.05%	-5.03%	-0.67%	-5.62%
FCF Yield	-2.27%	-9.89%	-4.57%	-5.41%	0.44%	0.01%
Buyback Yield / Dilution	-8.89%	-4.42%	-0.95%	-0.59%	-1.01%	8.85%

Source: S&P Global Market Intelligence. Standard template. Financial Sources.