Ionis Pharmaceuticals, Inc. (IONS)

Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Fiscal Year	Current	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Period Ending	Aug 13, 2025	Dec 31, 2024	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021	Dec 31, 2020
Market Capitalization	6,870	5,520	7,258	5,365	4,297	7,906
Market Cap Growth	-9.61%	-23.95%	35.28%	24.86%	-45.65%	-6.97%
Enterprise Value	6,561	5,024	6,991	4,631	3,606	6,615
Last Close Price	43.10	34.96	50.59	37.77	30.43	56.54
PS Ratio	7.13	7.83	9.22	9.13	5.30	10.84
PB Ratio	10.86	9.38	18.77	9.37	5.57	10.64
P/TBV Ratio	10.87	9.38	18.77	9.37	5.57	11.05
P/FCF Ratio	-	-	-	-	228.03	10240.42
P/OCF Ratio	-	-	-	-	139.52	220.26
EV/Sales Ratio	6.95	7.13	8.88	7.88	4.45	9.07
EV/FCF Ratio	-	-	-	-	191.38	8569.00
Debt / Equity Ratio	3.14	3.33	5.09	2.39	1.62	1.26
Debt / FCF Ratio	-	-	-	-	66.39	1217.15
Asset Turnover	0.33	0.24	0.28	0.23	0.32	0.26
Inventory Turnover	48.06	91.49	61.67	36.18	27.98	0.60
Quick Ratio	2.61	7.74	5.44	6.49	9.13	3.30
Current Ratio	2.87	8.47	5.90	7.07	9.75	3.56
Return on Equity (ROE)	-59.91%	-93.10%	-76.34%	-40.12%	-3.77%	-39.52%
Return on Assets (ROA)	-5.87%	-9.91%	-7.55%	-9.96%	-0.75%	-3.82%
Return on Capital (ROIC)	-6.85%	-12.12%	-9.71%	-12.93%	-1.02%	-5.18%
Earnings Yield	-3.90%	-8.22%	-5.05%	-5.03%	-0.67%	-5.62%
FCF Yield	-4.22%	-9.89%	-4.57%	-5.41%	0.44%	0.01%
Buyback Yield / Dilution	-7.95%	-4.42%	-0.95%	-0.59%	-1.01%	8.85%

Updated Jul 30, 2025. Source: S&P Global Market Intelligence. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q