Karyopharm Therapeutics Inc. (KPTI)

NASDAQ: KPTI · Real-Time Price · USD
4.450
+0.430 (10.70%)
At close: Aug 13, 2025, 4:00 PM
4.450
0.00 (0.00%)
After-hours: Aug 13, 2025, 4:10 PM EDT
10.70%
Market Cap 38.59M
Revenue (ttm) 137.27M
Net Income (ttm) -123.57M
Shares Out 8.67M
EPS (ttm) -14.62
PE Ratio n/a
Forward PE n/a
Dividend n/a
Ex-Dividend Date n/a
Volume 144,585
Open 4.110
Previous Close 4.020
Day's Range 4.110 - 4.500
52-Week Range 3.510 - 16.950
Beta 0.28
Analysts Buy
Price Target 39.80 (+794.38%)
Earnings Date Aug 11, 2025

About KPTI

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compound, include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myelom... [Read more]

Industry Biotechnology
Sector Healthcare
IPO Date Nov 6, 2013
Employees 279
Stock Exchange NASDAQ
Ticker Symbol KPTI
Full Company Profile

Financial Performance

In 2024, Karyopharm Therapeutics's revenue was $145.24 million, a decrease of -0.55% compared to the previous year's $146.03 million. Losses were -$76.42 million, -46.60% less than in 2023.

Financial Statements

Analyst Forecast

According to 6 analysts, the average rating for KPTI stock is "Buy." The 12-month stock price target is $39.8, which is an increase of 794.38% from the latest price.

Price Target
$39.8
(794.38% upside)
Analyst Consensus: Buy
Stock Forecasts

News

Karyopharm Therapeutics Inc. (KPTI) Q2 2025 Earnings Call Transcript

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Q2 2025 Earnings Call August 11, 2025 8:00 AM ET Company Participants Brendan Twohig Strong - Corporate Participant SVP of Investor Relations & Corporate Co...

2 days ago - Seeking Alpha

Karyopharm Reports Second Quarter 2025 Financial Results and Highlights Recent Company Progress

– New Patient Screening for Phase 3 SENTRY Trial in Myelofibrosis Expected to Close This Week; Top-Line Results Anticipated in March 2026 – – Total Revenue was $37.9 Million; U.S. XPOVIO® (selinexor) ...

2 days ago - PRNewsWire

Karyopharm to Report Second Quarter 2025 Financial Results on August 11, 2025

-- Conference Call Scheduled for Monday, August 11, 2025, at 8:00 a.m. ET -- NEWTON, Mass.

8 days ago - PRNewsWire

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

NEWTON, Mass. , Aug. 1, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company ...

12 days ago - PRNewsWire

Karyopharm to Present at the Jefferies Global Healthcare Conference

NEWTON, Mass. , June 3, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company'...

2 months ago - PRNewsWire

Karyopharm to Participate at the 2025 RBC Capital Markets Global Healthcare Conference

NEWTON, Mass. , May 19, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company'...

3 months ago - PRNewsWire

Karyopharm Announces Poster Presentation on Selinexor in Myelofibrosis at the 2025 European Hematology Association Annual Meeting

NEWTON, Mass. , May 14, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced its abstract has ...

3 months ago - PRNewsWire

These Analysts Revise Their Forecasts On Karyopharm Therapeutics After Q1 Results

Karyopharm Therapeutics Inc. KPTI reported mixed financial results for the first quarter on Monday.

3 months ago - Benzinga

Karyopharm Therapeutics Inc. (KPTI) Q1 2025 Earnings Call Transcript

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Q1 2025 Earnings Conference Call May 12, 2025 4:30 PM ET Company Participants Brendan Strong - Senior Vice President, Investor Relations & Corporate Communi...

3 months ago - Seeking Alpha

Karyopharm Reports First Quarter 2025 Financial Results and Announces New Data in Myelofibrosis that Further Suggests Selinexor May Lead to Meaningful Spleen Volume Reduction, Symptom Improvement, Hemoglobin Stabilization and Disease Modification

– New Randomized Phase 2 Monotherapy Data from XPORT-MF-035 Trial in a Hard-to-Treat Patient Population Further Strengthens Conviction in Selinexor's Potential in Combination with Ruxolitinib in JAKi-...

3 months ago - PRNewsWire

Karyopharm to Report First Quarter 2025 Financial Results on May 12, 2025

-- Conference Call Scheduled for Monday, May 12, 2025, at 4:30 p.m. ET -- NEWTON, Mass.

3 months ago - PRNewsWire

XPOVIO® (selinexor) Approved for Commercialization in Indonesia, Further Expanding Antengene's Commercial Presence in APAC

- XPOVIO ® is the first and only approved XPO1 inhibitor in Indonesia. - From the second half of 2024 to now, XPOVIO ®  was successively approved in Thailand, Malaysia and Indonesia, significantly exp...

5 months ago - PRNewsWire

Karyopharm Announces 1-for-15 Reverse Stock Split

NEWTON, Mass. , Feb. 24, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that it will imp...

6 months ago - PRNewsWire

Karyopharm Therapeutics Inc. (KPTI) Q4 2024 Earnings Call Transcript

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Q4 2024 Earnings Call February 19, 2025 8:00 AM ET Company Participants Brendan Strong - SVP, IR Richard Paulson - President and CEO Reshma Rangwala - CMO &...

6 months ago - Seeking Alpha

Karyopharm Reports Fourth Quarter and Full Year 2024 Financial Results, Announces Update to Phase 3 XPORT-EC-042 Trial and Highlights Recent Company Progress

– Total Revenue of $145 Million and U.S. XPOVIO® (selinexor) Net Product Revenue of $113 Million for Full Year 2024 – – Top-Line Data Readout from Phase 3 SENTRY Trial Evaluating Selinexor in Combinat...

6 months ago - PRNewsWire

Antengene Announces XPOVIO® Approved for Public Health Insurance Coverage in Taiwan Market, Benefiting More Patients with R/R MM in the Region

XPOVIO® is the first XPO1 inhibitor approved in Taiwan for the treatment of adult patients with relapsed/refractory multiple myeloma (R/R MM). After the mainland of China, South Korea, Australia and S...

6 months ago - PRNewsWire

Karyopharm to Report Fourth Quarter and Full Year 2024 Financial Results on February 19, 2025

-- Conference Call Scheduled for Wednesday, February 19, 2025, at 8:00 a.m. ET -- NEWTON, Mass.

6 months ago - PRNewsWire

Karyopharm Announces Preliminary Unaudited 2024 Revenue and 2025 Objectives

– Opportunity to Define a New Myelofibrosis Treatment Paradigm with Top-Line Data Readout from Phase 3 SENTRY Trial Evaluating Selinexor in Combination with Ruxolitinib in Patients with JAKi-Naïve Mye...

7 months ago - PRNewsWire

Karyopharm Announces the Appointment of Lori Macomber as Chief Financial Officer

NEWTON, Mass. , Jan. 2, 2025 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced the appointment o...

7 months ago - PRNewsWire

Karyopharm Announces the Appointment of Brendan Strong as Senior Vice President of Investor Relations and Corporate Communications

NEWTON, Mass. , Dec. 9, 2024 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced the appointment o...

8 months ago - PRNewsWire

Karyopharm Therapeutics Provides Endometrial Cancer Program Update

NEWTON, Mass. , Dec. 3, 2024 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that it is in dis...

9 months ago - PRNewsWire

Karyopharm to Participate at the Piper Sandler 36th Annual Healthcare Conference

NEWTON, Mass. , Nov. 25, 2024 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company...

9 months ago - PRNewsWire

Karyopharm Therapeutics Announces the Appointment of Chief Accounting Officer

NEWTON, Mass. , Nov. 20, 2024 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that Kristin Aba...

9 months ago - PRNewsWire

Karyopharm to Present Selinexor Data at the 66th American Society of Hematology Annual Meeting and Exposition

NEWTON, Mass. , Nov. 18, 2024 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced abstracts detail...

9 months ago - PRNewsWire

Karyopharm Therapeutics Inc. (KPTI) Q3 2024 Earnings Call Transcript

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) Q3 2024 Earnings Conference Call November 5, 2024 8:00 AM ET Company Participants Elhan Webb - Senior Vice President, Investor Relations Richard Paulson - P...

10 months ago - Seeking Alpha