Spruce Biosciences, Inc. (SPRB)

NASDAQ: SPRB · Real-Time Price · USD
79.99
-10.45 (-11.55%)
At close: Dec 5, 2025, 4:00 PM EST
80.02
+0.03 (0.04%)
After-hours: Dec 5, 2025, 7:43 PM EST
-11.55%
Market Cap 85.62M
Revenue (ttm) 697,000
Net Income (ttm) -47.88M
Shares Out 1.07M
EPS (ttm) -82.48
PE Ratio n/a
Forward PE n/a
Dividend n/a
Ex-Dividend Date n/a
Volume 154,247
Open 86.00
Previous Close 90.44
Day's Range 78.00 - 86.00
52-Week Range 4.28 - 240.00
Beta 3.51
Analysts Hold
Price Target 152.17 (+90.24%)
Earnings Date Nov 10, 2025

About SPRB

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, including anhedonia, weight alterations, and altered sle... [Read more]

Industry Biotechnology
Sector Healthcare
Founded 2014
Employees 21
Stock Exchange NASDAQ
Ticker Symbol SPRB
Full Company Profile

Financial Performance

In 2024, Spruce Biosciences's revenue was $4.91 million, a decrease of -51.32% compared to the previous year's $10.09 million. Losses were -$53.04 million, 10.7% more than in 2023.

Financial Statements

Analyst Forecast

According to 6 analysts, the average rating for SPRB stock is "Hold." The 12-month stock price target is $152.17, which is an increase of 90.24% from the latest price.

Price Target
$152.17
(90.24% upside)
Analyst Consensus: Hold
Stock Forecasts

News

Spruce Biosciences Reports Third Quarter 2025 Financial Results and Provides Corporate Updates

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological...

25 days ago - Business Wire

Spruce: BTD For TA-ERT For MPS IIIB Could Ignite BLA Submission With Added Bonuses (Rating Upgrade)

Spruce Biosciences received FDA Breakthrough Therapy Designation for TA-ERT in treating San Filippo Syndrome Type B [MPS IIIB]. BTD enables potential rolling BLA submission, Priority Review, and Accel...

2 months ago - Seeking Alpha

This Biotech Stock Soared 1,400%. Investors Are Optimistic About Its Rare-Disease Drug.

The microcap biotech stock had its best day ever after the FDA granted its rare-disease drug a breakthrough designation.

2 months ago - Barrons

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB)

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological...

2 months ago - Business Wire

Spruce Biosciences Resumes Trading on the Nasdaq Capital Market

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological...

2 months ago - Business Wire